The implication of p110δ in protective signals derived from bone marrow microenvironment seems to be the case also in MM since CAL-101 inhibited MM cells growth and Akt and P70S6K phosphorylation in cells treated with IL-6 and insulin growth factor-1 (IGF-1) or co-cultured with bone marrow stromal cells (Ikeda et al., 2010). Here, PIK3CD is linked to Miyoshi myopathy.