AKT1 and Hodgkins lymphoma: CAL-101 also decreased the phosphorylation of Akt and induced apoptosis in HL cell lines and moreover blocked the stroma cells-induced Akt activation in HL cells and disrupted the survival signals mediated by CCL5, CCL17, and CCL22 in co-cultures of HL cells with stromal cells (Meadows et al., 2012).