Other experiments have revealed that ZAP-70 functions as an adaptor protein in BCR signaling (Chen et al., 2008) and that the phosphorylation of Syk, PLCγ, and BLNK is enhanced in B-cell ZAP-70 positive compared to B-cell ZAP-70 negative CLL (Chen et al., 2005) which could indirectly alter the PI3K activity. Here, PIK3CA is linked to B-cell chronic lymphocytic leukemia.