PIK3CA and cancer: The multiple roles of mTORC1 and especially those correlated with mRNA translation and cell cycle has made the PI3K/Akt/mTORC1 axis an attractive target for the development of dual PI3K/mTOR inhibitors, mTOR-selective inhibitors and Akt inhibitors as anti-cancer drugs (Marinov et al., 2007; Sabbah et al., 2011; Castillo et al., 2012; Sheppard et al., 2012; Weigelt and Downward, 2012; Willems et al., 2012).