Significantly higher levels of p110δ PI3K activity have been determined in cells from patients with chronic lymphocytic leukemia (CLL) compared with normal hematopoietic cells (Herman et al., 2010) whereas overactivation of p110δ has also been found in multiple myeloma (MM) cell lines and cells from patients with MM (Ikeda et al., 2010) as well as in cell lines and cells from patients with Hodgkin's lymphoma (HL) (Meadows et al., 2012). Here, PIK3CA is linked to B-cell chronic lymphocytic leukemia.