PTEN and B-cell chronic lymphocytic leukemia: Reduced PTEN activity has also been found in CLL (Shehata et al., 2010) which might be a result of overexpression and overactivation of CK2 that were also detected in CLL and blockade of CK2 decreased PTEN phosphorylation leading to PTEN activation (Shehata et al., 2010; Martins et al., 2011).