There are also evidence documenting no correlation between the oncogenic activity of p110α PI3K and signaling through Akt (Gymnopoulos et al., 2007; Zhao and Vogt, 2008b; Vasudevan et al., 2009) suggesting that Akt can be a non-obligatory partner in PI3K signaling and that Akt-independent PI3K pathways may be important in cancer cells. This evidence concerns the gene PIK3CD and cancer.