PIK3CA and cancer: Further data have also suggested a promising role of p110δ PI3K in oncogenesis and cancers of non-hematopoietic origin (Knobbe and Reifenberger, 2003; Mizoguchi et al., 2004; Boller et al., 2008; Zhao and Vogt, 2008a; Jia et al., 2009; Vogt et al., 2009; Jiang et al., 2010; Tzenaki et al., 2012).