Inhibition of p-Akt and p-ERKInhibition of B-CLL survivalInhibition of TNFα-, BAFF- and CD40L-induced survivalInhibition of protective effects provided by fibronectin, stomal cells or NLCDecreased secretion of CCL2 and CCL3 from CLL cells, CXCL13 from stromal cells, various survival factors from NLCInhibition of chemotaxis of B-CLL to CXCL12, CXCL13, S1P and stromal cell linesDepletion of MZ B cells from the spleen. This evidence concerns the gene CXCL12 and B-cell chronic lymphocytic leukemia.