AKT1 and acute myeloid leukemia: Treatment of these cells with the p110δ-specific inhibitor IC87114, suppressed the constitutive Akt activation (Sujobert et al., 2005; Billottet et al., 2006) to equal levels as those observed upon the pan-PI3K inhibitor LY294002 treatment (Sujobert et al., 2005) confirming that the p110δ is the main isoform contributor of PI3K activity in AML cells.