The p110δ-isoform specific functions were demonstrated by mice with inactivated p110δ (Clayton et al., 2002; Jou et al., 2002; Okkenhaug et al., 2002; Ali et al., 2004; Aksoy et al., 2012) and by p110δ-selective inhibitors such as the IC87114 compound, which was the first isoform-selective inhibitor published (Sadhu et al., 2003), and the CAL101 which has recently entered clinical studies for hematologic malignancies (Fruman and Rommel, 2011; Castillo et al., 2012). Here, PIK3CD is linked to hematologic disorder.