CD8 CTL specific for HIV-1, HSV-2, and EBV HLA-B*27 and HLA-B*57 restricted epitopes were resistant to Treg cell-mediated suppression, explaining how such cells continue to proliferate and control infection(s) in LTNP, which might also apply to the virus-specific CD4 T cells. The gene discussed is HLA-B; the disease is infection.