TRPC6 and focal segmental glomerulosclerosis: TRPC6 is the core member of TRPC superfamily [2, 3], which maintains normal kidney function by regulating [Ca2+]i (intracellular calcium ion concentration) and is involved in a number of kidney diseases [4, 5].Changes in intracellular calcium signaling pathways caused by mutations or abnormal expression of TRPC6 lead to various kidney proliferation diseases [6], such as focal segmental glomerulosclerosis (FSGS), minimal change disease (MCD), and membranous glomerulonephritis (MGN).