Both the presence of oxLDL in air-pouch lavages from infected wild-type mice and restoration of agrIII antagonism by addition of oxLDL, but not LDL, to the air-pouch of 4APP-treated Nox2−/− mice, indicates that Nox2-mediated apoB control of agrIII-dependent signaling works directly at the site of infection to prevent agr type III-dependent signaling and its pathological consequences. This evidence concerns the gene APOB and infection.