Given that mRNA expression levels of RIOK1 and RIOK2 did not show significant upregulation in tumor samples with PTEN and/or EGFR alterations (Table S9), and given that RIOK1 and/or RIOK2 levels decline after short-term treatments with Akt inhibitors (Figure S7), we hypothesized that Akt signaling may regulate RIOK2 and/or RIOK1 levels by modulating protein stability post-translationally. The gene discussed is RIOK1; the disease is neoplasm.