In a panel of standard GBM cell lines, RIOK1 and RIOK2 showed strong expression in cell lines known to harbor PTEN and/or EGFR mutations, and RIOK1 and RIOK2 expression was comparatively lower in a GBM cell line with intact PTEN (Figure S5) [38], [39]. Here, RIOK2 is linked to glioblastoma.