To date, several studies have provided suggestive evidence that the RIO kinases could be involved in RTK and PI3K signaling: RIOK2 becomes rapidly phosphorylated in response to EGFR stimulation; Rio2p binds to Tor2p, an ortholog of the mTor kinase, and RIOK1 is required for the proliferation and survival of Ras-dependent cancer cells [21], [22], [23]. This evidence concerns the gene RIOK2 and cancer.