Akt is phosphorylated on Serine-473 by mTor-complex-2 (TORC2), a multi-protein complex composed of the mTor kinase and several other signaling components, including Rictor [46], a protein that becomes elevated in glioblastomas that also drives gliomagenesis when overexpressed in astrocytic cells [48], [49]. This evidence concerns the gene CRTC2 and glioblastoma.