ERBB2 and hepatocellular carcinoma: Increased full length Notch1 has been reported in HCC-1896 and MDA MB 231 (ErbB2 normal) cells after treatment with the ErbB1/2 inhibitor, gefitinib [13] and ErbB2 inhibition caused increased Notch1 receptor activity in ErbB2 overexpressing cell lines [11].