TNFSF10 and cancer: Further, we have shown that treatment of cervical (HeLa), ovarian, (PA-1) and thyroid (WRO) cancer cells devoid of expression of the endogenous MADD are more susceptible to both spontaneous and TRAIL- and TNFα-induced apoptosis [5], [11]–[13], primarily through the activation of the extrinsic apoptotic pathway.