Interestingly, the two patients from which HBCEC #335 and #360 were generated, presented with lymph node metastases (N1) whereas the patient of HBCEC #338 albeit being classified N0 was at high-risk in developing metastatic disease (grading 3, pT1c, pN0, Her2 3+). Here, ERBB2 is linked to metastatic neoplasm.