Zinc finger, DHHC-type containing 2 (ZDHHC2), one member of DHHC protein family of PATs, originally named as reduced expression associated with metastasis protein (REAM), is located in chromosome 8p21.3-22 [10], where frequent loss of heterozygosity has been detected in various types of metastatic cancers, including prostate cancer [11], hepatocellular carcinoma [12], colorectal cancer [13], non-small cell lung cancer [13], [14], urinary bladder [15], breast cancer [16], [17]. This evidence concerns the gene ZDHHC2 and metastatic malignant neoplasm.