ZDHHC2 and metastatic malignant neoplasm: ZDHHC2 is located in chromosome 8p21.3-22 [10], where frequent loss of heterozygosity has been detected in various types of metastatic cancers [11], [12], [13], [14], [15], [16], [17], and somatic mutations of this gene were found in colorectal cancer, hepatocellular carcinoma, and nonsmall lung cancer [10].