ZDHHC2, one member of ZDHHC family, originally named as reduced expression associated with metastasis protein (REAM), has been proposed as a putative tumor/metastasis suppressor gene, and the mRNA level of ZDHHC2 expression was found to be significantly reduced in primary and metastatic foci of advanced colorectal cancer [10], However, ZDHHC2 expression pattern has not yet been investigated in gastric adenocarcinoma. The gene discussed is ZDHHC2; the disease is colorectal cancer.