To investigate the association between ZDHHC2 expression and clinicopathological parameters of gastric cancer patients, paraffin-embedded tissues section (n = 472) with histopathologically confirmed gastric adenocarcinoma were examined using immunohistochemistry, and low expression of ZDHHC2 was observed in 44.7% (211/472) of gastric cancer patients. Here, ZDHHC2 is linked to gastric adenocarcinoma.