GYPA and malaria: Mapping of the epitope to the F2 β-finger region will facilitate further advancements in mechanistic studies evaluating the interactions between EBA-175 and glycophorin A binding upon host cell invasion by the malaria parasite, and most importantly, the development of assays such as a competitive ELISA to assess the possible function of natural [17] and vaccine [35] induced human EBA-175 RII specific antibodies.