Aberrant expression of the ecotropic viral integration site 1 (EVI1) gene, which in healthy individuals is transcribed in hematopoietic stem and progenitor cells but not in mature blood cells [1], [2], [3], [4], is associated with a poor prognosis in myeloid leukemias [2], [5], [6], [7], [8], [9], [10], [11], [12], [13]. Here, MECOM is linked to myeloid leukemia.