Agents used for chemotherapy in AML like etoposide and anthracyclines induced CDKN1A/p21/WAF in a variety of cell types, including hematopoietic cells [29], [31], [32], [33], [34], [37], [39], and p21 protected hematopoietic cells from apoptosis [29], [30], [31], [33], [35], [36]. Here, CDKN1A is linked to acute myeloid leukemia.