Of the top two regions, KCNIP4 and PDZD2/GOLPH3/MTMR12/ZFR, only KCNIP4 had gene-level replication in the SHARP AHR GWAS at a nominally significant level in the same regions as the asthma GWAS studies [Figure 7]. This evidence concerns the gene KCNIP4 and asthma.