Among them, EGFR(7p11.2) [48], TWIST1(7p21.2) [49], RAC1(7p22) [50], MTDH(8q22.1) [51], CCNE2(8q22.1) [52], TNFRSF11B(8q24) [53] and GRB2(17q25) [54] might be good candidates, as they are reportedly associated with invasiveness and metastasis of tumor cells. This evidence concerns the gene GRB2 and neoplasm.