In contrast to the drug interventions, removal of the dietary overload by switching to a low-fat chow diet (DLI group) demonstrates the ability to re-establish a “healthy” phenotype on most investigated levels, i.e. traditional risk factors of T2DM (fasting glucose, fasting insulin, body weight and adiposity), cardiovascular risk factors (cholesterol, triglycerides) and diabetic complications in liver (steatosis) and kidney (microalbuminuria). This evidence concerns the gene INS and type 2 diabetes mellitus.