By indirect comparisons of the three classes, IR dopamine agonists appeared to be the most effective for reducing “OFF” time (at −1.54 h/day vs. −0.83 for COMT inhibitors and −0.93 for MAO-B inhibitors), but the agonists (and the COMT inhibitors) carried a higher risk for dyskinesias than did the MAO-B inhibitors (Stowe et al. 2010). This evidence concerns the gene COMT and Dyskinesia.