Although there have been many advances in our understanding of other key pathways involved in cancer such as Wnt/beta-catenin [190], Notch [191] and hedgehog [192], we have primarily focused on the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways due to space considerations. The gene discussed is PIK3CB; the disease is cancer.