The dual PI3K/PDK1 inhibitor NVP-BAG956 was determined in one study to exert the most powerful cytotoxic affects against T-ALL cell lines and primary patients samples, in comparison to a pan class I PI3K inhibitor (GDC-0941), an allosteric Akt inhibitor (MK-2206), an mTORC1 allosteric inhibitor (RAD-001), or an ATP-competitive mTORC1/mTORC2 inhibitor (KU63794). This evidence concerns the gene PIK3CB and acute lymphoblastic leukemia.