In contrast, ectopic expression of NGAL did alter the sensitivity of MCF-7 breast cancer cells to targeted therapy [178] MCF-7/NGAL were more sensitive to EGFR, Bcl-2 and calmodulin kinase inhibitors as well as the natural plant product berberine than MCF-7 cells infected with the empty retroviral vector pLXSN. This evidence concerns the gene LCN2 and breast cancer.