CCND1 and neoplasm: In addition to oncogenic lncRNAs, recent studies have identified several examples of tumor-suppressor lncRNAs that could phenotypically affect cells by promoting tumor-suppressor pathways, which, when compromised, prone cells to develop cancer, e.g., a set of low-abundance lncRNAs, produced from the cyclin D1 (CCND1) promoter region, were shown to allosterically modulate the activity of a key transcriptional regulatory sensor of DNA damage signals, a RNA-binding protein known as translocated in liposarcoma (TLS) [74].