IRF3 and Increased total eosinophil count: In wild-type mice and IPS-1−/−mice, the poly IC treatment significantly augmented the eosinophilia in BALF, but it did not in TRIF−/−mice or IRF-3−/−mice (Figure 2B), suggesting that the TRIF-IRF-3 pathway is essential for the poly IC-induced augmentation of airway eosinophilia.