The results presented here portraits that radiation robustly increased nuclear translocation and DNA binding activity of NFκB, transactivation of 53 NFκB family, signaling and effector molecules and further resulted in activation of TNFα, AKT1/2/3, SOD2 and ERK1/2 at least in surviving hypoxic breast cancer cells. The gene discussed is NFKB1; the disease is breast carcinoma.