The results precisely demonstrated that phytochemicals including neem leaf extract, genistein, resveratrol, raspberry extract, curcumin and, its synthetic analogue EF24 have significant impact on attenuating radiation modulated NFκB nuclear import, DNA-binding activity, signaling pathway transcriptome and on the translational activation of its signaling (TNFα, AKT1/2/3, SOD2 and ERK1/2) and effector (Birc 1, 2, 5) proteins in surviving hypoxic breast cancer cells. The gene discussed is TNF; the disease is breast cancer.