The results precisely demonstrated that phytochemicals including neem leaf extract, genistein, resveratrol, raspberry extract, curcumin and, its synthetic analogue EF24 have significant impact on attenuating radiation modulated NFκB nuclear import, DNA-binding activity, signaling pathway transcriptome and on the translational activation of its signaling (TNFα, AKT1/2/3, SOD2 and ERK1/2) and effector (Birc 1, 2, 5) proteins in surviving hypoxic breast cancer cells. This evidence concerns the gene NFKB1 and breast cancer.