HELLS and coronary artery disorder: Three transcripts were dramatically up-regulated (TNFRSF10B, TNFRSF21, NGF) and six transcripts that were down-regulated (EPR1, BIRC5, HELLS, BCL2, TNFRSF1B, CASP1) in the CAD+DM group relative to the CAD group (Table 3).