Although patients showing absence of A-type lamins are rare, a family with autosomal dominant EMD has been reported with a heterozygous lamin A/C nonsense mutation (Q6X) [63], and a case of limb-girdle muscular dystrophy has been described with a heterozygous lamin A/C nonsense mutation (Y259X), both of which lead to lamin A/C haploinsufficiency. This evidence concerns the gene LMNA and limb-girdle muscular dystrophy.