Although a role for CASP2 in DRGN apoptosis has not been identified, CASP2 does mediate apoptosis in hippocampal neurons, sympathetic neurons [10], [11], retinal ganglion cells [12], pancreatic acinar cells and insulin secreting (HIT-T15) cells [13], cancer cells [14] and murine macrophages [15]. This evidence concerns the gene CASP2 and cancer.