Among the adhesion molecules which play a key role in the spreading of the neoplastic cells to the mesothelial monolayer, several studies pointed to the specific function of the intercellular adhesion molecule 1 (ICAM1) present on the mesothelial cells in promoting the process [10], [21]; in addition, it has been shown that the up-modulation of its expression, as a result of oxidative stress and senescence of the peritoneal cells, promotes the adhesion of neoplastic cells from ovarian, gastric and colon cancers [22]–[24], demonstrating the general and crucial role of ICAM1 in the spreading. The gene discussed is ICAM1; the disease is colonic neoplasm.