These acquired senescent state led to an increase in the adhesion of the cancer cells, which was inhibited by the addition of serial dilutions of a blocking anti-ICAM1 antibody, strengthening the role of ICAM1 in the adhesion process and suggesting that this ICAM1-mediated molecular interaction might be even more crucial for cells floating in the peritoneal fluid from which our cultures are derived. Here, ICAM1 is linked to cancer.