In contrast to previously published data, however [28], both GBM cell lines in which PKM2 levels were suppressed exhibited an accumulation of G2/M cells based on their 4n DNA content (Fig 4I) as well as an increase in expression of enzymes associated with G2 arrest (cdc25c, cyclin B, not shown) relative to scramble controls. The gene discussed is PKM; the disease is glioblastoma.