RelB controls EMT and the expression of the mesenchymal genes in glioma, including YKL-40/CHI3L1 (Figure 3B), a secreted glycoprotein that is a prognostic indicator for poor survival in high-grade glioma as well as other cancers and inflammatory diseases [16], [21], [35]. The gene discussed is CHI3L1; the disease is central nervous system cancer.