RBFOX3 and microphthalmia: In addition to microphthalmia, Rereom/eyes3 mice have a high level of perinatal mortality, postnatal growth deficiency, brain hypoplasia, decreased numbers of neuronal nuclear antigen (NeuN)-positive hippocampal neurons, hearing loss, cardiovascular malformations, spontaneous development of cardiac fibrosis in adulthood and renal agenesis.