To determine if RERE deficiency can cause hearing loss in mice, we examined the startle responses of wild-type, Rere+/eyes3, Rere+/om and Rereom/eyes3 littermates at P21 to a 108 dB sound burst at 19.9 kHz emitted from a click box, a common screening test for severe hearing loss. The gene discussed is RERE; the disease is hearing loss disorder.