GJB2 and deafness: It has been demonstrated that the allele frequencies of several common deafness mutations are higher than 1% in the general population, e.g., GJB2 p.V37I (∼10% in some East Asian general populations) [43], [44], c.235delC (∼1.5% in the Chinese general population) [45], and c.35delG (∼1.3% in the European general population) [46].