Curcumin also affected NF-κB–regulated gene products involved in apoptosis (caspase-3, -8, -9, PARP, Bax), anti-apoptosis (Bcl-xL) and proliferation (cyclin D1), thereby suppressing cell proliferation and potentiating 5-FU-induced apoptosis in CRC cells. This evidence concerns the gene CASP3 and colorectal carcinoma.