Curcumin also affected NF-κB–regulated gene products involved in apoptosis (caspase-3, -8, -9, PARP, Bax), anti-apoptosis (Bcl-xL) and proliferation (cyclin D1), thereby suppressing cell proliferation and potentiating 5-FU-induced apoptosis in CRC cells. The gene discussed is CCND1; the disease is colorectal carcinoma.