However, we are able to identify major hubs among the modules, such as MP and MAPK, in the categories of HGG and others, respectively; some may even be obviously LGG associated, such as AAM. In addition, the tissue-specificity of gliomas is blurred by AP and other five vertices including PD, ALS, AD, HUD and PAD, which are common for neurodegenerative diseases and other neuro-pathological conditions. The gene discussed is PPP1CB; the disease is central nervous system cancer.