We analyzed AKAP4 protein expression in all histotypes using anti-AKAP4 antibodies which revealed AKAP4 protein localization in 100% DCIS (4/4) (Figure 3), 83% IDC (69/83) (Figure 4, 5) and 100% ILC (4/4) (Figure 6) patient’s specimens (Table 1) suggesting its importance for developing as a biomarker. The gene discussed is AKAP4; the disease is ductal breast carcinoma in situ.