The strongest association between ITGAM and risk of SLE is with the minor allele of a non-synonymous SNP, rs1143679 (odds ratio 1.4–2.17), which converts the arginine at amino acid position 77 to a histidine (R77H, minor allele frequency of ∼10% in European American individuals) [9]–[11]. Here, ITGAM is linked to systemic lupus erythematosus.