Notably, chemokine C-X-C motif receptor 4 (CXCR4; 7-transmembrane G-protein chemokine receptor for CXCL12) was up-regulated, and docking protein 2 (DOK2; the substrate of chmeric p210bcr/abl oncoprotein) and interleukin 2 receptor, gamma (IL2RG; interleukin receptor common gamma chain for IL2, IL4, IL7, IL9, IL15, and IL21) were down-regulated with tumor progression, while expressions of these three genes changed in the opposite direction after chemotherapy. The gene discussed is IL21; the disease is neoplasm.