PIK3CD and neoplasm: On the other hand, Phospholipase C, gamma 1 (PLCG1; guanine nucleotide exchange factor for nuclear GTPase), Phosphoinositide-3-kinase, catalytic, delta polypeptide (PIK3CD; autophosphorylation activity), and Protein kinase C, zeta (PRKCZ; atypical isozyme of the serine-threonine protein kinase C) which showed decreased expressions with tumor progression were further down-regulated with chemotherapy, while STAT1 which showed an increased expression with tumor progression was further up-regulated with chemotherapy.