The putative gene target of miR-103, Ptplb, is essential for biosynthesis of tyrosine phosphatase-like member b, which is involved in a wide range of neuronal functions, including synapse formation [70], disorders involving the frontal cortex such as Alzheimer’s disease [71], [72] and schizophrenia [73]. This evidence concerns the gene HACD2 and early-onset autosomal dominant Alzheimer disease.