Considering the B-NHL cells and primary B-ALL cells that have down regulated hPEBP4 were more sensitive to rituximab-induced death, hPEBP4 may be a new target for adjuvant therapy for B-NHL patients and that downregulation of hPEBP4 might represent a promising adjuvant regimen along with rituximab for B-cell lymphoma treatment. Here, PEBP4 is linked to precursor B-cell acute lymphoblastic leukemia.