These observations are consistent with the previous finding that HB-EGF-CTF on the cell surface translocate to the inner nuclear membrane [13], full-length forms of HB-EGF did not translocate to the nucleus in the gut cells overexpressing unshed HB-EGF-CTF [22], and the suppression of nuclear translocation of HB-EGF-CTF abrogated cell proliferation in gastric cancer cells [23]. The gene discussed is HBEGF; the disease is gastric cancer.