TP53 and cancer: Wang et al. 2011, showed that the naturally occurring isothiocyanates (ITCs) phenetyl isoisothiocyanate (PEITC), derived from watercress plant, and the synthetic ITC, 2,2-di phenetyl isoisothiocyanate selectively deplete mutant, but not the wild-type p53, and induce apoptosis in many cancer cells, including the MDA-MB-231 breast cancer cells [43].