We found that most SUZ12 targets in hepatocellular carcinoma and embryonic fibroblast, including EPCAM, IGFII, DKK1, HEY2, CCNA1, CCND2, DAB2IP, BMP6, PAX4, DLX5, LHX1, NEFL, NEUROG1, NEUROG2, NMU, SHH, showed little expression change in our PCa cell microarray data when treated by DHT; meanwhile, BAMBI and MASS1 targeted by SUZ12 are down-regulated. The gene discussed is IGF2; the disease is posterior cortical atrophy.