There was a significantly reduced frequency of MGMT promoter methylation in gemistocytic tumours (2/15, 13% vs 91/232, 26%, p = 0.03, Fishers exact test), and a significantly greater frequency in oligodendroglial (32/59, 54% vs 61/188, 32%, p = 0.001, Fishers exact test) and giant cell (7/11, 64% vs 86/236, 36%, p = 0.05, Fishers exact test), despite the different prognoses of these latter two morphological subgroups. This evidence concerns the gene MGMT and neoplasm.