Oligodendroglial and small cell morphologies were significantly over-represented in the younger age group (13/60, 22% vs 9%, p = 0.006; 4/19, 21% vs 28/257, p = 0.039, Fishers exact test) as well as those tumours with IDH1 mutation (3/59, 5% vs 5/215, 2%, p = 0.08; 2/19, 11%, 6/255, 2%, p = 0.04, Fishers exact test). The gene discussed is IDH1; the disease is neoplasm.