For example, latency network predicted targeting interactions that are in agreement with previously reported biochemical interactions, e.g., of KPNB1 with HSPA9; VCP with NCL; HNRNPA1 with HNRPF; KPNA2 with TXNIP; HNRPF with HNRPM; ACIN1 with SF3B4; and HNRPH1 with SFRS3, etc. In addition, 10 interactions were overlapped among the latency, LTNP and control condition, indicating that gene regulation was reprogrammed in different infection state. The gene discussed is NUCLEOLIN; the disease is infection.