A better understanding of why their function is disturbed in SHRs, may improve our understanding of the pathological mechanisms causing not only spontaneous hypertension, but also other conditions involving α2AR, such as diabetes type II and behavior and cognitive disorders (Hunt et al., 1995; Crassous et al., 2007; Fagerholm et al., 2011). Here, ADORA2A is linked to type 2 diabetes mellitus.