Our previous studies showed that of several ion channels, it was mainly the calcium channels (Orai1/STIM1, TRPV6) and potassium channels (IKCa1, BKCa) that were involved in the generation of the SOCE in human PCa cells (Flourakis et al. [2010]; Lallet-Daher et al. [2009]; Vanden Abeele et al. [2003a,, b]). The gene discussed is STIM1; the disease is posterior cortical atrophy.