MAPK3 and pituitary tumor: In pituitary tumor cells (GH3/B6/F10 rat Somatomammotropes), Kochukov et al. ([2009]) showed that BPA at a 1 nM concentration induced a great increase in Ca2+ oscillation frequency, the activation of MAPK pathways (ERK1/2) and subsequently a PRL release (Kochukov et al. [2009]).