It has been proposed recently that perinuclear localization of Eag could lead to the activation of MARP pathway resulting in increased cell proliferation.36 Therefore, it is possible that overexpression of Eag induces the activation of p38 MAPK which then promotes the proliferation of osteosarcoma cells because we showed that the inhibition of p38 MAPK/p53 pathway led to reduced MG-63 cell proliferation. This evidence concerns the gene TP53 and osteosarcoma.