Previous study has shown that Eag interferes with oxygen homeostasis by increasing HIF-1 activity and VEGF secretion, thus promoting tumor vascularization.6 In this study our in vitro data using imipramine, a nonspecific blocker of Eag conduction activity, indicated that the proliferation of osteosarcoma cells depends on the K+ conducting activity of Eag. Here, VEGFA is linked to neoplasm.