Despite this, the combined analysis of all sample sets produced an association signal at the threshold of genome-wide significance only for 2p25 (rs300774), with the associated SNPs on 2p25 falling in a large linkage disequilibrium block containing the ACP1 (acid phosphatase 1) gene, a gene whose expression was significantly elevated in people with bipolar disorder who committed suicide. The gene discussed is ACP1; the disease is bipolar disorder.