IFNG and infection: Similarly, engagement of TLR on DCs by Mtb surface molecules could induce the expression of IL-12 by DCs, which in turn could activate NK cells to express the genes encoding IFN-γ through upregulation of CD69. In summary, the canonical pathway for the communication between DC and NK cells is consistent with and supported by our observations on individual networks involved in the activation of these two immune cell types, which are highly upregulated as early as 2 weeks post-infection.