The goal of this study was to determine whether, in a Sprague Dawley (SD) rat model of type 1 diabetes mellitus, middle-dose[16] curcumin could protect ICCs in diabetic rats with delayed gastric emptying by reducing oxidative stress and inhibiting NF-κB activation, increasing SCF/Kit expression, and normalizing the delay in gastric emptying. This evidence concerns the gene NFKB1 and diabetes mellitus.