CREBBP and Rubinstein-Taybi syndrome: In addition to memory deficits, several CBP deficient strains, including cbp+/- mice and cbpkix/kix mice bearing a point mutation within the KIX domain that blocked CBP-CREB interaction, exhibited impaired motor skill learning [54, 93], that may resemble the difficulty in planning motor acts and executing locomotor skills that RSTS patients are reported to experience [94].