TP53 and neoplasm: Attenuation of p53 function, however, is invariably associated with increased tumour formation in mammals, which is, instead, absent in the long-lived mice (Hursting et al., 1994; Migliaccio et al., 1999; Ikeno et al., 2003, 2009; Giorgio et al., 2005; Alderman et al., 2009).