Eleven potential candidate genes for ocular melanosis were selected: agouti signaling protein (ASIP), catechol-o-methyltransferase (COMT), glycoprotein NMB (GPNMB), glycogen synthase kinase 3-beta (GSK3B), lysosomal trafficking regulator (LYST), melanocortin 1 receptor (MCIR), microphthalmia transcription factor (MITF), silver (SILV), tyrosinase (TYR), tyrosinase related protein 1 (TYRP1), and Tyrosinase related protein 2 (TYRP2). The gene discussed is COMT; the disease is Ocular melanocytosis.