NRG1 variants have been associated with dysfunction in a number of schizophrenia-relevant “endophenotypes” including sensorimotor gating as measured by prepulse inhibition of startle (PPI) (Hong et al., 2008; Roussos et al., 2011; Greenwood et al., 2012) and working memory (Chong et al., 2008). Here, NRG1 is linked to schizophrenia.