Adolescent Nrg1 HET mice displayed a trend toward increased expression of the pro-apoptotic and inflammatory cytokine TNF-α in the hippocampus and schizophrenia patients with a missense mutation in the transmembrane domain of NRG1 show heightened expression of TNF-α from B cells (Marballi et al., 2010; Desbonnet et al., 2012). The gene discussed is NRG1; the disease is schizophrenia.