Among those, the heterozygous transmembrane domain Nrg1 mutant mouse (Nrg1 HET) has shown compelling face, construct, and partial predictive validity for schizophrenia research (Stefansson et al., 2002; Karl et al., 2007, 2011; Van Den Buuse et al., 2009; Duffy et al., 2010; Chesworth et al., 2012a,b). The gene discussed is NRG1; the disease is schizophrenia.